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In this model, rats displayed marked cognitive deficits accompanied by oxidative damage, as indicated by increased MDA levels and reduced SOD activity in brain tissue

J Pharmacol Exp Ther 308(2):658666 Hamilton TC, Winker MA, Louie KG, Batist G, Behrens BC, Tsuruo T, Grotzinger KR, McKoy WM, Young RC, Ozols RF (1985) Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion