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Dosing & Uses Dosage Forms & Strengths tablet 0.5mg 1mg Smoking Cessation Set a date to stop smoking and begin varenicline 1 week before this date Alternatively, the patient can begin varenicline and then quit smoking between days 8 and 35 of treatment Also see Administration Quit smoking date regimen Initiate regimen 1 week before quit smoking date Days 1-3: 0.5 mg PO qDay Days 4-7: 0.5 mg PO BID Day 8 to end of treatment: 1 mg PO BID If quitting is successful after 12 weeks, continue another 12 weeks at 1 mg q12hr Gradual approach to quitting For patients who are sure that they are not able or willing to quit abruptly, consider a gradual approach to quitting smoking with varenicline Begin dosing and reduce smoking by 50% from baseline within the first 4 weeks, by an additional 50% in the next 4 weeks, and continue reducing with the goal of reaching complete abstinence by 12 weeks Continue varenicline for an additional 12 weeks, for a total of 24 weeks of treatment Encourage patients to attempt quitting sooner if they feel ready Dosage Modifications Consider a temporary or permanent dose reduction in patients who cannot tolerate the adverse effects Renal impairment Mild-to-moderate (CrCl 30 mL/min): No dosage adjustment required Severe (CrCl 10% Nausea (15-40%

In a case control study of 1114 patients with oropharyngeal cancer, Blot et al

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