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However, epidemiological studies assessing Swedish smokeless tobacco, which exposes users to nicotine without combustion products, generally have not found an increased risk of myocardial infarction or stroke among users, but suggest that nicotine might contribute to acute cardiovascular events, especially in those with underlying coronary heart disease

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Research on the processes that transform Sph-1 into a toxic protein is likely to be central for our understanding of PD and how neural metabolism contributes to this disease 36,37,38

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