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By Category: Closed Systems Dominate Despite Open-System Growth Closed vaping systems held 82.62% market share in 2025, benefiting from brand loyalty, regulatory clarity, and retail convenience, while open systems will grow at 1.89% CAGR through 2031 as enthusiasts prioritize customization over simplicity

Although most of the research studying conditioned effects of alcohol associate it to its reinforcing effects mediated by its enhancement of GABAergic, opioid and dopaminergic systems, it is possible that the KD-induced bioenergetic switch from glucose to ketones is also relevant to its reinforcing effects, particularly given that energy-rich stimuli engender strong conditioned responses (8, 27, 28)

So why do the media keep saying e-cigarettes are bad if they are so much better than cigarettes