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Through extensive legal, scientific, and regulatory analyses, FDA developed a science-based, iterative research process for developing new cigarette health warnings to put forth in this proposed rule that would advance the Government's substantial interest in promoting greater public understanding of the negative health consequences of smoking

But certain patterns should immediately make you think, I need to see a doctor. Persistent upper abdominal pain Often in the upper abdomen, sometimes radiating to the back May be worse at night or when lying down Pain in the mid-back Dull ache where a bra strap would sit (for women) or mid-spine discomfort Unintentional weight loss and loss of appetite Clothes becoming loose without trying Early fullness, bloating, indigestion Jaundice (pilia) Yellowing of eyes and skin Dark urine, pale/clay-coloured stools, itching Often due to a tumour blocking the bile duct New-onset diabetes or a sudden change in diabetes control Diabetes diagnosed after age 4050 with unexplained weight loss or abdominal pain Existing diabetes suddenly becomes hard to control Persistent digestive problems Nausea, vomiting, bloating Oily or floating stools (steatorrhea) due to poor fat digestion Unusual fatigue, blood clots, or leg swelling Deep vein thrombosis (DVT) in the legs can, in some cases, be linked with pancreatic cancer

Schulz JD, Hawkes EL, Shaw CA