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There are few studies examining acute nicotine administration in non-smokers, due to the nature of tobacco use disorder and the all-or-nothing tendency for people to be regular smokers or non-smokers

10.1176/ajp.150.4.546 52

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Importantly, recent studies have established that the myoepithelial cell serves as the stem cell of the murine SMG, and can also regenerate surface epithelia in settings of severe injury 41,42