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When someone engages in smoking or consumes other addictive substances, such as drugs, the activity or substance stimulates the release of dopamine in the brains reward pathway

You will go out to the store or to the club or to the cafe and smell that unique saffron-ambroxan sillage on yourself or someone around you, and this will happen hundreds of times and then suddenly not at all, and then in five years or ten you will smell it again and be thrown back to here and now

The cumulative effect is that these stressors cause animals to be less reliable and less representative of human biology (7)