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Signs of an overdose including the following: confusion unconsciousness (unable to wake someone up when you shout or shake them) severe nausea and vomiting having a fit difficulty breathing snoring or raspy breathing blue/pale tingeing of knees, hands, and lips slow or erratic pulse (heartbeat) pale, cold, and clammy skin If you think somebody is overdosing, put them in the recovery position (on their side) and call an ambulance as soon as you can

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Importantly, smokers have a worse prognosis than nonsmokers [158], with higher rates of recurrence, progression, mortality, and increased treatment complications such as surgery and radiation difficulties