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Further studies suggested that the vapors generated by e-cigarettes increased the tolerance and inflammatory potential of pathogenic bacteria similar to the smoke of traditional cigarettes [60]

The main challenge is taste

Sales of e-cigarettes with greater than 5% nicotine increased to 81% in 2022 90% More than 90% of disposable e-cigarettes sold contained the highest levels of nicotine 46% Nearly half (46%) of high schoolers who vape do so near daily Rapidly rising nicotine levels in e-cigarettes risk addicting young people In 2022, over 2.5 million middle and high school students reported using e-cigarettes, according to the National Youth Tobacco Survey, with nearly half (46%) of high schoolers who vape doing so near daily, putting them on a trajectory for a potential lifetime of nicotine addiction

Changes in taste or texture : Expired lozenges may taste different, feel chalkier, dissolve unevenly, or take longer to dissolve