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Research from the New England Journal of Medicine has concluded that substance use including nicotine causes the following changes in the brain: Desensitizes the brains reward circuit, dampening the brains ability to feel pleasure and motivation in everyday activities Increases the strength and intensity of conditioned responses, including reactivity to stress, which in turn produces stronger cravings for alcohol and other drugsas well as negative emotions when cravings go unsatisfied Weakens regions of the brain involved in executive functioning, like decision-making, impulse control and self-regulationall of which increase your relapse potential E-cigarettes are not safe for anyone, period