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These pathological changes compromise airway integrity and immune regulation, thereby heightening the susceptibility to asthma in older adults

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One major limitation is the incomplete knowledge of the metabolic pathways and transformations that polyphenols undergo after ingestion, particularly due to interactions with the gut microbiome and the formation of diverse metabolites whose biological activities are not well characterized ( There is also a critical need for well-designed long-term safety studies addressing the potential side effects of chronic polyphenol supplementation, as current data are mainly limited to short-term animal experiments or isolated compounds, and results from these do not always translate directly to humans ( Clinical research on polyphenol bioavailability is advancing, but large-scale intervention trials remain scarce

And then, as mentioned above, Republic Tobacco, the manufacturer and distributor of the "new" U.S