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This public or population health standard is quite high and requires considering the products risks and benefits to the population as a whole, including users and nonusers of the tobacco product, and taking into account the increased or decreased likelihood that existing users of tobacco products will stop using such products, and the increased or decreased likelihood that those who do not use tobacco products will start using such products

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Leveraging new understandings of disease biology and technical advances shows promise for mitigating the diverse manifestations of smoking-induced illness (Barungi et al