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Older children and adults are sometimes affected There is a prodrome with high fever and a sore throat Initially macular lesions appear on the buccal mucosa, tongue, and / or hard palate , which rapidly progress to vesicles that erode and become surrounded by an erythematous halo Cutaneous lesions , arising as tender macules or vesicles on an erythematous base, develop in 75% of cases

Smokers testes and accessory glands were observed to have inflammation which results in damaged sperm

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