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NNMT: a novel pharmaceutical target (Frontiers review, 2024)

Standard GLP-1 contraindications still apply Compounded semaglutide has safety risks and contraindications to consider: Semaglutide is not indicated for patients with a personal or family history of thyroid tumors, particularly medullary thyroid carcinoma (MTC) and neuroendocrine tumors such as MEN 2 (multiple endocrine neoplasia) type 2 syndrome

Therefore, NNMT is expected to act as an effective cancer therapeutic target in BRCA1 -deficient ovary tumor ( Figure 1 NNMT is also involved in regulating autophagy to maintain cancer cell survival via the mTOR and AMPK pathways

Metabolic protection: Unlike traditional calorie restriction, research suggests tirzepatide does not significantly impair metabolic adaptation, meaning your metabolism is better protected