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Smoking Facts at a Glance Worldwide Smoking is the leading cause of premature, preventable death globally.[1] [2] Tobacco kills up to half of its long-term users, which equates to around 7.5 million deaths a year globally.[2] [3] Around 5.8 million of those deaths are the result of direct tobacco use while around 1.7 million are the result of non-smokers being exposed to second-hand smoke