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Chemicals in Cigarettes: List of Toxins In Cigarettes What Does Your Garage and a Cigarette Have in Common? American Lung Association Cigarette smoke is made up of thousands of chemicals, and among them is hydrogen cyanide a highly toxic substance also found in certain poisons. It's created when tobacco burns and is Smoke doesn't just stay in the air; it can linger in the spaces people live and work in. Secondhand and thirdhand smoke can leave harmful chemicals in the air and on surfaces

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