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Poor oral hygiene and ill-fitting dentures, which cause chronic inflammation, are also considered possible risk factors

While the clinical implications of these findings remain uncertain, the presence of such molecular alterations raises concerns that habitual marijuana use may establish a pro-oncogenic microenvironment within the bronchial epithelium

One study found that a 10% increase in cigarette price led to a 27% increase in little cigar sales, but increasing little cigar prices by 10% led to a 32% decrease in little cigar sales