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45,46 TAMs compose 50% of the total cell population in situ 47 and are primarily derived from cytokine-recruited macrophages that are secreted by TME stromal cells and cancer cells, and include CCL2, CCL5, and CSF1

Using a within-subjects design minimised the potentially confounding effects of inter-individual differences in responses to THC and CBD [32], while confounding effects of previous cannabis use and of placebo responses were reduced by ensuring that the participants were infrequent users and were blind to the content of the preparations

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It was all novelty for me, the pipe, the smoke, the high, and I was excited that I was having this authentic experience, this once-in-a-lifetime experience that I was never, never going to do again