can chewing tobacco cause ulcers doesn't just affect your lungs — it seriously damage your mouth and throat too. Smoking and tobacco expose oral tissues to harmful cancer-causing chemicals, increasing the risk of serious How Smoking and Tobacco Silently

third, add alcohol

There is far, far more to this than just numbers and measurements and the sooner those of us who are generally on side with harm reduction can get those who are ideologically opposed to harm reduction (and that is *exactly* what it is, given the very strong evidence of the relative harms from e-cigs and lit tobacco there is now no excuse to claim otherwise) to stop spreading their utter crap in the press be it mendacious statistics twiddling (such as in the US, where they deliberately conflate lit tobacco which kills and smokeless tobacco of any kind which quite simply, does not), or openly lying, as recently done by a senior tobacco control wonk in Australia, where it was claimed that smoking levels in the US havent dropped but have in fact risen

This is backed by real research not just opinion

Generalized additive models: an introduction with R