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de Koning HJ, van der Aalst CM, de Jong PA, Scholten ET, Nackaerts K, Heuvelmans MA, Lammers JJ, Weenink C, Yousaf-Khan U, Horeweg N, et al

White, male and female Wistar rats, aged three months (average body weight: 361 g male and 189 g female), born and reared in the Animal House of the Department of Toxicology, at the Poznan University of Medical Sciences, Poznan, Poland, were housed in polypropylene cages (33 17.8 40 cm) (n = 1 rat/cage) with autoclaved pine sawdust litter under controlled environmental conditions (12 h light/dark cycle: 7 am7 pm

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Jawbone deterioration occurs when a missing tooth causes the section of the jawbone that tooth was connected with to no longer get the exercise it needs to maintain itself