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Take a look at the possible adverse reactions associated with the medication: Diarrhea Vomiting and nausea Severe weight loss Gingival Hyperplasia (the overgrowth of gums) Swollen gums (often involving excessive bleeding and discomfort) Tremors Headaches Kidney failure Hypertension Cancer Changes in hearing Changes in vision Lethargy and depression Muscle weakness Bruising Jaundice (yellowing of the eyes, gums, and skin) Development of infections Loss of consciousness Lack of coordination (ataxia) Also, since these drugs merely suppress the symptoms, your dog can quickly become dependent