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[40] The author of the novel, Anthony Burgess, also believed the phrase "as queer as a clockwork orange" was Cockney slang having heard it in a London pub in 1945, and subsequently named it in the title of his book

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The actions of insulin and related proteins, including its receptors and insulin-like growth factor-1 (IGF-1), have been associated with increased tumor growth, particularly for colon, breast, and prostate cancer 49