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According to the Mayo Clinic, nicotine can cause permanent damage to the developing fetus' brain and other organs not to mention the risk posed by other chemicals and additives in e-cigarettes

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Examples of such circumstances include if new information becomes available that no longer make an MRTP order permissible, if the product no longer reduces risk or exposure based on data from postmarket surveillance or studies, or if the applicant failed to conduct or submit postmarket surveillance or studies