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These models can also account for important feedback mechanisms that have been, for the most part, ignored by existing aggregate models

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Molecular mechanisms and physiologic functions of mitochondrial dynamics

It is similar to the concepts of fetal programming and Barkers hypothesis, which illustrate the relationship between a specific path of growthconsisting of slow growth in utero and rapidly increasing BMI in postnatal periodand the development of chronic diseases later in life, such as coronary heart disease and related disorders including stroke, hypertension and non-insulin dependent diabetes 55,56