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First, the bias covariates used, although carefully extracted and evaluated, were based on observable study characteristics and thus may not fully capture unobserved characteristics such as study quality or context, which might be major sources of bias

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Vapes, especially disposables, usually come labeled with: Puff count (e.g., 2000, 5000, 10000 puffs) Nicotine strength (e.g., 2%, 5%, or written as 20mg/mL or 50mg/mL) E-liquid capacity (e.g., 10mL, 15mL) Lets say youre using a 5% nicotine disposable vape with 10mL of e-liquid