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Thus, it is reasonable to imagine that in order to execute such response, these bacteria should follow a sequence of events involving: (i) sensing of unfavorable conditions, (ii) entry into a persistent state, (iii) survival in adverse conditions, (iv) sensing of favorable conditions, (iv) exit from persistence, and (v) resume to normal production of infectious progeny (Figure 1B)

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[1] Truth is well aware of the record declines in youth smoking and vaping, at least when taking credit for them

Nicotine can worsen insulin resistance, disrupt glucose control, and increase the likelihood of heart disease and other complications