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For example, there were large increases in smoking RRs and RDs for all-cause mortality and lung cancer mortality in the United States (US) between the 1960s, 1980s and 2000s 8

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Cigarette smoke can also be harmful to pet birds and small pets such as rabbits and guinea pigs, as they have very sensitive respiratory systems

Therefore, we aim to test a secondary hypothesis that baseline nicotine metabolite ratio (NMR) will moderate the experimental treatment effect, such that the benefit of dose titration will be greater in those participants who are rapid metabolizers of nicotine, and the final titrated dose they reach will be higher on average than the slow metabolizers