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Although some evidence from small, early trials suggested that patients with a history of opiate dependence might be susceptible to dysphoric effects in response to naltrexone (Crowley et al

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In several studies using animal models, it was discovered that nicotine exposure results in increased risk of cardiovascular disease (CVD) in the exposed offspring later in life (i.e., high BP, dyslipidemia, and increase in vascular tone) [16, 17]