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Philip Morris said that a few participants in an early stage of the trial produced unusually large volumes of urine. Because medical tests showed no problems with the subjects, the company said, the investigator did not initially consider the samples to be adverse events. After discussion with the medical monitors of the study as well as Philip Morris, the investigator ultimately decided to mark these incidences as adverse events, the company said

A primary care provider is likely to refer you to an ear, nose, and throat doctor (doctor of otolaryngology) for treatment or to confirm their diagnosis