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Compared to adults, adolescent nicotine users experience more episodes of depression and cardiac irregularities, and they are more likely to become quickly and persistently nicotine dependent

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Owing to concerns about variability in U-Cr values as a function of age, sex, race/ethnicity, and body size, it is recommended that the creatinine-adjusted concentration of an analyte for an individual be compared with a reference value obtained on a similar demographic group (e.g., adults with adults, children with children) [16]