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First, re-twist the base inwards a 180 twist helps compact the contents

With this study, we have found that people who smoke a pack a day develop an average of 150 extra mutations in their lungs every year, which explains why smokers have such a higher risk of developing lung cancer. Additionally, other organs were also affected and the study showed that a pack a day led to an estimated average 97 mutations in each cell in the larynx, 39 mutations for the pharynx, 23 mutations for the mouth, 18 mutations for the bladder, and 6 mutations in every cell of the liver each year

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