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Moreover, the random effects rely on the strong assumption of a normal distribution, making the group-specific coefficients biased toward the overall mean regression coefficient

Harms include: -25% increased risk of any fracture and a 40% increase in the risk of hip fractures among men -healing after injury -Increased risk of back and neck pain, leading to a 79% increase in chronic back pain and a 114% increase in disabling lower back pain -Significant cause of rheumatoid arthritis and can reduce the impact of treatment Brain Current smokers are 53% more likely to develop cognitive impairment than non-smokers and 59% more likely to develop Alzheimers disease Teeth Smoking increases the likelihood of tooth loss and decay Eyes Smoking damages sight by increasing the risk of age-related macular degeneration (AMD) by 78%-358% and increasing the risk of age-related cataracts With New Years resolutions approaching and two thirds of smokers saying they want to quit, new adverts are being used to graphically illustrate the degeneration that smoking causes