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Early in 1970s, researchers started to recognize that cigarette smoking could induce decline in pulmonary function in adults ( Of note, early life exposure to cigarette smoking predicts development of COPD in adults ( in utero and early life represents an important risk factor for development of COPD in adulthood ( To date, multifaceted mechanisms of oxidative stress, inflammation, and tissue destruction have been implicated in the pathogenesis of COPD ( According to the official American Thoracic Society policy statement in 2010, the estimated population-attributable fraction (PAF) of smoking for COPD was almost 80% in most countries/areas ( Environmental Pollutions Environmental exposure (including ambient/outdoor and household air pollutions) is a non-selective and unavoidable traditional risk factor for COPD that has synergistic effects with cigarette smoking in inducing COPD-related morbidity and mortality ( 2

Basically, they used the unreliable narrator to justify their retcon of the gang smoking

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