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Liquid chromatography and mass spectrometry conditions Analyses of urinary nicotine, cotinine and NNAL were conducted using an HPLC (UltiMate 3000, Thermo Fisher Scientific, Yokohama, Japan) coupled to a hybrid quadrupole-Orbitrap mass spectrometer (Thermo Scientific Q Exactive Focus) with heated electrospray ionization (HESI-II)

However, I thought the battery life was a major weakness of the disposable pen

Their activism is built on the assumption that removing external smoking cues, restricting e-cigarette marketing to adults for example, is the best way to discourage vaping, which is clearly not the case for depressed patients

Tolerance build-up: Over time, the body may build up a tolerance to nicotine, requiring higher doses to achieve the same stimulating effects