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Major health organizations, including the Centers for Disease Control and Prevention (CDC) and the National Cancer Institute, emphasize that nicotine replacement therapy is significantly safer than continued smoking

The inclusion criteria and results of the systematic review approach are reported in accordance with PRISMA guidelines 31

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Effective correction requires a sequential protocol: first removing surface pigmented cells through controlled exfoliation, then targeting active melanin production with corrective ingredients at effective concentrations, then reinforcing the tissue barrier to prevent recurrence