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FIGURE 3 Formaldehyde (FA) is as environmental contaminant with toxic potential that also serves as an indispensable and thus normal physiological metabolite in the healthy brain, where it is hypothesized to regulate learning and memory via the N -methyl-D-aspartate receptor ( 3 ) impairs cognitive function, including memory, in humans, causing neuronal damage and oxidative stress in the cerebellum of experimental animals, and inducing the misfolding of neuronal tau and related proteins in vitro ( 4 Pathway changes associated with cellular damage and inflammation in brain A systematic review of the effects of active and passive smoking of conventional cigarettes, electronic cigarettes and tobacco heating products indicated that active and passive smoking induce oxidative stress and inflammatory responses in peripheral tissues ( e.g
Some have reported systemic effects, such as headaches, neck aches, and other symptoms
What complicates this even more is that when these chemicals burn, they form other chemicals that may have additional effects on health. While tobacco companies like R.J