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[159] The lowest published toxic dose (TDLO) is reported to be 27mg/kg in males and 104mg/kg in females while the estimated medial lethal dose (LD50) is 150mg/kg in mice and 251mg/kg in rats

We included all pregnant women with data on the exposure of interest (prenatal maternal smoking or SHS) and children in whom neurodevelopment was assessed using BSID-III at any time point from infancy to toddlerhood, along with data on maternal age at childbirth and household income level

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