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In the case of DPT and AM only numbers of GST-P-positive foci improvement were significant, which suggest that these compounds may increase the probability of liver tumor formation (67)

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Oxidation of low-molecular-weight thiols, like Cys and GSH, results in the formation of disulfides and a 2:1 (thiol:oxidant) stoichiometry indicates the participation of a sulfenic acid intermediate

More recently, base editing approaches have been applied to fine-tune the catalytic efficiency of enzymes such as APX1, resulting in improved ROS detoxification under stress conditions