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While its primary job is to neutralize free radicals and support liver health, researchers discovered that it also has a significant impact on the melanogenesis pathway

Parkinsons Dis 2011:716871

These results suggest that the highly conserved positively charged residue K200 in GIRK2 supports a dynamic interaction with PIP 2 that decreases the channels open probability in the absence of other modulators (G, ethanol) ( 2 binding site alter the selectivity of GIRK2 for different PIPs (Qiao et al., 2020)