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Arrondo E, Iida N, Hashimoto T, Ozaki H, Shibuki T, Imai M, Fujisawa T, Nakamura Y, Bando H, Kopetz S , Shen JP, Yoshino T

confirmed that the up-regulation of Drp1 induced by high glucose promoted the release of hexokinase-II from mitochondria, which subsequently inhibited the PINK1/Parkin pathway of mitophagy, leading to retinal damage in DR