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E N D Presentation Transcript PHASE II DRUG METABOLISM: Glucuronidation and Sulfation General properties of Phase II metabolism Introduction to glucuronidation Substrates for UGTs UGT structure Properties of glucuronides Methods to characterize glucuronides Disposition and reactions of glucuronides UGT pharmacogenetics, polymorphism, variability Sulfotransferases N-Acetylation, Aminoacid conjugation, Glutathione conjugation Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Recommended Reading: Gonzales and Tukey, Drug Metabolism, In: Goodman and Gilmans, The Pharmacological Basis of Therapeutics, 11th Edition, 2005, Chapter 3

Cells were incubated with a mouse monoclonal antibody targeting the human transferrin receptor (Clone H68.4, #136800, Invitrogen, Eugene, OR) diluted to a final concentration of 2 g/mL in PBS overnight at 4 C

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Previous studies on drivers of gentrification include the development of parks and green spaces, urban renewal projects, mass transit station constructions, and disaster prevention improvements