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is supported by the NIH National Institute on Aging (grant RF1AG55549) and National Institute of Neurological Disorders and Stroke (grants R01NS107265 and RO1AG062135)

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We found that increasing pre-rRNA synthesis by ncl-1 RNAi exacerbated mitochondrial stress, while stress was alleviated by the Pol I-constraining tif-1A RNAi (Fig