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The SARS-CoV-2 viral N protein has been found to increase the synthesis of IL-6, which has been linked to the downregulation of glutamate cysteine ligase (GCL), the rate-limiting enzyme in GSH synthesis [12,13]

Still, it influences the release of TGF-1, the activation and proliferation of fibroblasts, and their differentiation into myofibroblasts, mostly mediated by the RANKL/NF-B pathway