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Pathological studies have shown that iNOS-expressing macrophages can be detected in AAV lesions, suggesting that the metabolic reprogramming of arginine toward the NO pathway is closely associated with the activation of pro-inflammatory macrophages (102)

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In the paper, they analyzed data from the Etiology of Pneumonia in the Community (EPIC) Study, a prospective active surveillance study of 1,735 adults admitted to the hospital with clinical and radiographic evidence of pneumonia