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One study found that in cases in which diarrhea persisted even after a gluten-free diet, there was a significantly higher prevalence of laboratory signs of pancreatic insufficiency

Outside of genetic causes, copper has been found to be decreased in the Parkinsons disease brain corresponding to diminished cuproenzyme metallation and function linked to pathology 50,51,52,53,54

2.1.2 NDDS developed based on different enzyme systems in the gastrointestinal tract The gastrointestinal tract harbors an intricate enzymatic network that functions as highly specialized molecular shears, cleaving chemical bonds in most pharmaceutical compounds and rendering them biologically inactive prior to reaching their target sites ( Chitosan is a linear polysaccharide formed by randomly distributed N-acetyl-D-glucosamine and D-glucosamine units connected by (14) glucoside bonds (Figure 2A)