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JY and WM provided guidance, edited and revised the manuscript, and is responsible for all aspects of the manuscript

For instance, MOTS-c is a mitochondrial-derived peptide that also activates AMPK and specifically targets muscle tissue, making it an excellent alternative or cyclic companion to AICAR

They have employed VSEARCH, a clustering method, UCLUST, Quantitative Insights Into Microbial Ecology (QIIME) and the Silva 132 database for assigning OTUs at the genus and species level [189]