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bioRxiv , 2023.2006.2027.546764 (2023)

EYE SUPPLEMENTS FOR ADULTS : A 12-week human clinical study at the University of North Texas showed that 40mg of CapsiClear Capsanthin provided significant support for increased MPOD (macular pigment optical density) that positively influenced photostress recovery and blue-light resistance

The proposed mechanism suggests that caffeine and other coffee compounds absorbed through the colonic mucosa might stimulate the liver's production of glutathione S-transferase, an enzyme involved in detoxification pathways