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LSM 0.72) of advanced fibrosis at biopsy compared to those for non-alcoholic fatty liver disease (NAFLD)

DFO could improve cell survival more effectively than Fer-1, possibly due to the iron-chelating effect of DFO, and reduce the rate of the Fenton reaction, thereby causing a proportion of drug molecules to be uninvolved in the reaction

The in vitro results indicated that perillyl alcohol inhibited the NF-B pathway and promoted the nuclear translocation of Nrf2, thereby reducing the levels of proinflammatory cytokines (IL-1, IL-6, and TNF-), ROS, and COX-2 while increasing the viability of macrophages

It demonstrates cytostatic and pro-apoptotic effects across various malignancies through modulation of multiple signaling pathways (Sudhakaran et al., 2023