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Pseudoporphyria a genetically heterogenous condition characterized by hyperkalemia, hyperchloremic acidosis, low or suppressed renin activity, and normal to high concentrations of aldosterone

The unique binding sites of isatuximab and daratumumab may explain their differential in vitro abilities to inhibit the CD38 enzymatic activity and to induce different structural changes within the CD38 molecule upon binding

Clinical trials showed blood pressure reductions of 6-8 mmHg systolic on average

The peptide does not bind to growth hormone receptors in muscle tissue, does not stimulate protein synthesis or muscle hypertrophy, shows no effects on bone metabolism or growth, demonstrates no organ enlargement or proliferative effects, and avoids the connective tissue changes associated with growth hormone