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Using Parkin-null (Park / ) flies, a study showed that folic acid supplementation improved the motor dysfunction and decreases hydrogen peroxide and glutathione redox imbalance [175] where as in fly homozygous for Parkin mutation (c00062), folic acid supplementation improved the mortality, locomotory defect, oxidative stress by alleviating mitochondrial dysfunction associated with Parkin mutation [176]

Moreover, Gastrodin also ameliorates osteoporosis by blocking the formation, maturation, and migration of osteoclasts through the inhibition of the NFATc1 gene and specific transmembrane protein DC-STAMP ( WSS25 is a sulfated polysaccharide extracted from the rhizome of Rhizoma Gastrodiae

After abdominal disinfection, a vertical abdominal midline incision was made under xiphoid process